Gather all ingredients in a clean workspace.

In a large bowl, mix ground turkey, breadcrumbs, egg, garlic powder, onion powder, salt, and pepper until well combined.

Shape the mixture into four equal patties about 1 inch thick with an indentation in the center.

Preheat your grill to medium heat (375°F). Lightly oil the grates.

Cook patties for 6-7 minutes per side until they reach an internal temperature of 165°F.

Let patties rest for a few minutes before serving on toasted buns with desired toppings.