Preheat the oven to 350°F (175°C).

In a large bowl, mix ground turkey, breadcrumbs, egg, onion, garlic powder, Worcestershire sauce, salt, and pepper until well combined.

Shape the mixture into a loaf and place it in a baking dish.

Spread ketchup and brown sugar over the top of the meatloaf.

Bake in the oven for 70 minutes or until fully cooked.

Let it rest for a few minutes before slicing and serving.