In a mixing bowl, combine ground turkey, garlic powder, onion powder, salt, black pepper, Worcestershire sauce, beaten egg, and bread crumbs. Mix until just combined.

Divide the mixture into 4 equal portions and shape them into patties.

Preheat the grill to medium-high heat.

Place the patties on the grill and cook for about 5-7 minutes on each side, or until the internal temperature reaches 165°F (74°C).

If using cheese, place a slice on each patty during the last minute of cooking to melt.

Toast the burger buns on the grill if desired.

Place each patty on a bun and top with lettuce, tomato, pickles, ketchup, and mustard as desired.